You initial post refers to the Advanced Serial Port Monitor software, therefore I've asked about ASDL.
Please,
1. move all plugins to the initial location
2. activate the program protocol file. It is possible the program generates any error messages (look at the attached image)
Also, I can try to connect your PC with help of our remote support tool and fix this problem shortly.
Remote support tool:
http://www.aggsoft.com/aggsoft-remote-support.exe